Ovarian cancer
Conditions
Interventions
IOC2 Monitoring Group:IOC2 was used as a pain monitor to adjust opioid dosage during surgery
Control Group:The dosage of opioids was adjusted according to standardized anesthesia (patients vital signs such as heart rate and blood pressure)
Sponsors
Affiliated Cancer Hospital of Nanjing Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Age = 18 years and = 64 years. 2. Preoperative diagnosis of ovarian cancer via biopsy. 3. American Society of Aneshesiologists (ASA) II-III classification. 4. BMI 18.5-28 kg/m². 5. Preoperatively received at least 3 cycles of neoadjuvant chemotherapy with a combination of paclitaxel and carboplatin (21 days/cycle), followed by imaging assessment and Fagotti scoring 2 weeks later, indicating suitability for surgery under total intravenous anesthesia for open abdominal cytoreductive surgery of malignant ovarian tumors.
Exclusion criteria
Exclusion criteria: 1. Planned laparoscopic or robotic surgery. 2. History of long-term alcohol, opioid, or other analgesic use (= 3 months). 3. Allergies to anesthetic agents. 4. Emergency surgery. 5. History of radiotherapy or other chemotherapy regimens. 6. Patient is pregnant or breastfeeding. 7. Diagnosed with mental illness or other autonomic nervous system disorders that may affect Electroencephalogram (EEG) results. 8. Significant hepatic or renal dysfunction, or history of cardiopulmonary disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean intraoperative opioid consumption (MMEs); | — |
Secondary
| Measure | Time frame |
|---|---|
| The average amount of propofol used during the operation;Extubation time and recovery time upon admission to the PACU;The NRS scores for activity and resting state on the day of surgery (4 hours post-operation), the first day after surgery (24 hours post-operation), and the second day after surgery (48 hours post-operation);The use of rescue analgesics and antiemetics on the day of surgery (4 hours post-operation), the first day after surgery (24 hours post-operation), and the second day after surgery (48 hours post-operation);Postoperative 24-hour QoR-15 score, time to first flatus, time to first ambulation, pelvic drainage volume, postoperative hospital stay duration, and total length of hospital stay.;The highest NRS score in the PACU, the amount of morphine accumulated in the PACU; | — |
Countries
CHINA
Contacts
Public ContactXiaolan Gu
Affiliated Cancer Hospital of Nanjing Medical University
Outcome results
None listed