Obstructive sleep apnea syndrome
Conditions
Interventions
group A:esketamine 0.25 mg/kg was infused within 40min
group B:The same volume of normal saline as esketamine was infused within 40min
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) 18-70 years old; 2) Physical status ?-? of the American Society of Anesthesiologists; 3) Patients with OSAS who plan to undergo nasal surgery, tonsillectomy and adenoidectomy, uvulopalatopharyngoplasty (UPPP), weight loss metabolism surgery (BMS) and other general anesthesia operations under general anesthesia;
Exclusion criteria
Exclusion criteria: 1) recent history of fever infection; 2) Those who are unable to cooperate due to cognitive, linguistic, visual or hearing impairment or mental illness; 3) Application history of steroid or nonsteroidal anti-inflammatory drugs in recent 1 month; 4) History of severe respiratory or cardiovascular diseases; 5) There are contraindications for the use of estaketamine, such as severe hypertension, glaucoma, increased intracranial pressure and hyperthyroidism; 6) Refusing to sign the informed consent;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cytokines (IL-6TNF-aCPRIL-1ßIL-8IL-108-iso- PGF2aMDA 8-OHdG); | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative pain;quality of recovery;Autonomous breathing recovery time;Extubation time;PACU restlessness score;The incidence of remedial analgesia and remedial antiemesis;Mean arterial pressure (MAP);Heart rate;PACU residence time;Patient satisfaction score;Incidence of side effects of esketamine;Postoperative adverse events;Pain threshold and pain tolerance threshold;Epworth Sleepiness Scale score,ESS;Hospital Anxiety and Depression Scale score, HADS; | — |
Countries
China
Contacts
Public ContactYuan jingjing
First affiliated hospital of Zhengzhou university
Outcome results
None listed