at risk for growth retardation
Conditions
Interventions
iKids-Growth intervention group:iKids-Growth
Control group:None
Sponsors
Shanghai Children's Hospital
Eligibility
Sex/Gender
All
Age
5 Years to 10 Years
Inclusion criteria
Inclusion criteria: 1.Age 5-10 years, i.e. 5 years and above, under 11 years, excluding 11 years; 2.The height corresponding to the same sex and age is within the range of P3-P10; 3.The subject and/or guardian understand the purpose of the study, the possible risks and benefits of the study, agree to participate in the clinical study, and voluntarily sign the informed consent;
Exclusion criteria
Exclusion criteria: 1.Patients with abnormal blood glucose (fasting blood glucose =5.7mmol/L); 2.Undergoing growth hormone treatment; 3.Liver and kidney dysfunction (ALT> 1.5 times the upper limit of normal, Cr> the upper limit of normal). 4.Other diseases or factors causing growth disorders (growth hormone deficiency, attachment deprivation, Turner syndrome, Laron syndrome, skeletal dysplasia, etc.); 5.Patients who have used systemic or local hormone therapy (such as growth hormone, sex hormone, glucocorticoid, etc.) within 3 months and have received drug therapy that may interfere with GH secretion or GH effect (oxandrosterone, growth hormone-releasing hormone, etc.). 6.Subjects who are allergic to the dietary supplements used in this clinical trial. 7.Subjects who have participated in a drug clinical trial within the past 3 months. 8.Subjects whose guardians are with cognitive impairments. 9.Other conditions deemed unsuitable for inclusion in this clinical study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| annual height velocity;the improvement of height SDS; | — |
Secondary
| Measure | Time frame |
|---|---|
| IGF-1 and IGFBP-3;Bone age; | — |
Countries
China
Contacts
Public ContactJinjin Chen
Shanghai Children's Hospital
Outcome results
None listed