Thoracic diseases (mainly lung lesions)
Conditions
Interventions
Trial group (dexmedetomidine nasal spray group):Nasal spray with dexmedetomidine nasal spray
Control group (0.9 % physiological saline group):Nasal spray with 0.9 % physiological saline
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: A. Patients undergoing elective thoracoscopic surgery B. ASA classification I-III C. Age 18-65 years old, gender-neutral D. BMI: 18-28 kg/m^2 E. Obtaining informed consent from patient and signing the informed consent form
Exclusion criteria
Exclusion criteria: A. Contraindications to central venous puncture placement B. Subjects considered by the investigator to be unsuitable for nasal spray (e.g., severe rhinitis, nasal deformities, etc.) C. Patients with a history of myocardial infarction or unstable angina, heart rate<60 beats/minute, concomitant grade II or greater atrioventricular block, permanent pacemaker implantation, or severecardiac insufficiency D. Patients with a history of ischaemic stroke or transient ischaemic attack E. Abnormal liver and kidney function F. Combined with hypothyroidism G. Patients with comorbid sleep apnoea syndrome or difficult airway possibilities H. Individuals with intellectual retardation, cognitive dysfunction, and mental system disorders I. History of sedative or psychotropic substance abuse J. Allergy to anaesthetic drugs or ingredients relevant to this study K. Pregnant or lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sedation scores (Sedation success rate);Anxiety scores;Haemodynamic changes during double lumen tube intubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep scores: 1d before surgery, 1d and 2d after surgery ;MMSE scores: 1d before surgery, 1d and 2d after surgery ;Intraoperative anaesthetic and vasoactive drug dosage;Quality of postoperative recovery; | — |
Countries
China
Contacts
Public ContactYanhua Chen
The First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed