hypertension
Conditions
Interventions
Lactobacillus group:12 week probiotic lactobacillus intervention
placebo group :12 week placebo-controlled intervention
Sponsors
the First Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Age range: 18-75 years old (2) Meets the diagnostic criteria for refractory hypertension (taking three different types of antihypertensive drugs for more than 4 weeks, with each drug being the maximum dose or the patient's maximum tolerated dose, clinic blood pressure = 140/90mmHg, 24-hour average dynamic blood pressure = 130/80mmHg, or home blood pressure average = 135/85mmHg, or requiring the use of four antihypertensive drugs to meet the criteria, diagnosed as refractory hypertension)
Exclusion criteria
Exclusion criteria: (1) Pseudo refractory hypertension. (2) Merge serious diseases such as cardiovascular and cerebrovascular diseases, malnutrition, and thyroid diseases. (3) Combined with gastrointestinal diseases such as ulcerative colitis. (4) Have taken antibiotics or probiotic preparations in the past month (5) History of major gastrointestinal surgeries (such as subtotal gastrectomy) within the past five years (6) Complicated with infectious diseases, with obvious abnormalities in blood routine, procalcitonin and C-reactive protein
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fecal metagenomic testing;Plasma metabolomics testing; | — |
Countries
China
Contacts
Public ContactYue Li
the First Affiliated Hospital of Harbin Medical University
Outcome results
None listed