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Lactate-related gene patterns and the roles in metabolic reprogramming and histone lactylation/palmitoylation related epigenetic modulation in inflammatory bowel disease

The role and mechanism of lactate in the regulation of inflammatory bowel disease

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400091819
Enrollment
Unknown
Registered
2024-11-04
Start date
2023-03-01
Completion date
Unknown
Last updated
2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

inflammatory bowel disease

Interventions

health controls:no
UC:no
CD:no

Sponsors

Xiangya Hospital of Central South University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
21 Years to 70 Years

Inclusion criteria

Inclusion criteria: The diagnosis of IBD in the selected patients was based on the combination of clinical manifestations, serum and imaging data, endoscopic findings and histopathological examination by three experienced doctors

Exclusion criteria

Exclusion criteria: Exclusion criteria were as follows: (1) pregnant or lactating women; (2) Life-threatening conditions such as hematological diseases, tumors, active gastrointestinal bleeding, severe liver and kidney dysfunction, or recent cardiovascular and cerebrovascular accidents; (4) patients with severe infection requiring antibiotics; (5) complete intestinal obstruction or toxic megacolon requiring surgical treatment as soon as possible

Design outcomes

Primary

MeasureTime frame
lactate-related genes‘ expression;—

Secondary

MeasureTime frame
C-reactive protein;erythrocyte sedimentation rate;Calcium binding protein;Inflammatory factors;—

Countries

China

Contacts

Public ContactJun Yi

Xiangya Hospital of Central South University

junyee1989@csu.edu.cn+86 158 7428 7992

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026