Study on the relationship between different ventilation modes and postoperative pulmonary complications of esophageal carcinoma: A Single-Center, Prospective, Randomized Clinical Trial

Study on the relationship between different ventilation modes and postoperative pulmonary complications of esophageal carcinoma

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400091813

Enrollment

Unknown

Registered

2024-11-04

Start date

2024-11-06

Completion date

Unknown

Last updated

2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pulmonary complications of esophageal cancer

Interventions

Experimental group 1:VT-guided ventilation regulated by minimum driving pressure

Experimental group 2:Keep VT at 6 ml/kg and PEEP at 5 cmH2O

Eligibility

Sex/Gender

All

Age

19 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. ASA physical status I to III; 2. Patients aged 19 to 80 years; 3. Surgery for esophageal cancer requiring one-lung ventilation.

Exclusion criteria

Exclusion criteria: 1. Allergies to drugs in the study protocol; 2. Patients with serious complications such as respiratory failure, pulmonary infection, atelectasis, emphysema, pulmonary heart disease, pleurisy; 3. Taboo patients treated with PEEP: intracranial hypertension, bronchopleural fistula, hypoxic shock, right ventricular failure.

Design outcomes

Primary

Measure	Time frame
Incidence of pulmonary complications;	—

Secondary

Measure	Time frame
Postoperative extrapulmonary complications;Unplanned admission to ICU or re-hospitalization is required;Hospital mortality;	—

Countries

China

Contacts

Public ContactLonghui Cao

Sun Yat-Sen University Cancer Center

caolh@sysucc.org.cn+86 138 2609 2036

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026