Motoric Cognitive Risk, MCR
Conditions
Interventions
RIC group :Remote ischemic preconditioning
sham-RIC group:Sham remote ischemic preconditioning
Sponsors
Xuanwu Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age 65-80 years old, gender unlimited; 2.Can live independently (4ADLs: dressing, bathing, walking, bed chair transfer); 3.MCR diagnostic criteria: Walking speed Clinical diagnosis Slow walking (single task gait test) : male 65 to 74 years old, walking speed =75 years old, walking speed =75 years old, walking speed =12 years of education) /25 minutes (<12 years of education); 4.Good compliance with treatment and follow-up is expected; 5.Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Cognitive impairment caused by clinically diagnosed neurological degenerative diseases such as Alzheimer's disease, Lewy body dementia, frontotemporal dementia, and Parkinson's disease; 2.MMSE<=23; 3.History of brain tumor or mental illness, acute stroke <=6 months; 4.Cardiothrombotic disease, such as mitral stenosis and atrial fibrillation, myocardial infarction within six months, cardiac mural thrombosis or valve neoplasms, congestive heart failure, endocarditis; 5.Obvious abnormal bleeding/coagulation mechanism; 6.Severe liver and kidney insufficiency, malignant tumors, or the presence of serious diseases requiring medical intervention or surgery; 7.RIC treatment for soft tissue or vascular injury at the cuff compression site, or other conditions that cannot tolerate RIC; 8.Known causes of slow gait (non-neurological causes such as arthritis, heart disease, and neurological causes such as hemiplegia, ataxia, spasms, Parkinson's disease, and frontal lobe disease); 9.Pregnant or lactating women; 10.Life expectancy < 6 months or expected to undergo any surgery within 6 months; 11.Refusal to sign informed consent, poor compliance, or failure to cooperate with complete treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in 6-month and 9-month ADAS-cog total scores from baseline;The ratio of ?ADAS-cog<=-4 for 6 months and 9 months; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dementia conversion rate (MMSE) at 6 and 9 months;Fall risk at 6 months and 9 months;Changes from baseline for ADAS-cog’s 12 items at 6 and 9 months;6-month and 9-month executive ability assessment (MTT-A&B score), Social Functional Activity Questionnaire (FAQ), Daily Living Ability Scale (ADL) scores;Local skin lesions resulting from RIC physical therapy; | — |
Countries
China
Contacts
Public ContactHaiqing Song
Xuanwu Hospital Capital Medical University
Outcome results
None listed