Study on the Efficacy of Mindfulness Meditation Intervention Based on Brain-Computer Interface for Neuropsychological Rehabilitation in Patients with Amyotrophic Lateral Sclerosis (ALS)

Study on the Efficacy of Mindfulness Meditation Intervention Based on Brain-Computer Interface for Neuropsychological Rehabilitation in Patients with Amyotrophic Lateral Sclerosis (ALS) - Study on the Efficacy of Mindfulness Meditation Intervention Based on Wearable Brain-Computer Interface for Neuropsychological Rehabilitation in Patients with Amyotrophic Lateral Sclerosis (ALS)

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400091775

Enrollment

Unknown

Registered

2024-11-04

Start date

2024-11-04

Completion date

Unknown

Last updated

2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Amyotrophic Lateral Sclerosis (ALS)

Interventions

Experimental Group:Subjects practiced meditation using the Brain-Computer Interface Positive Mind Meditation System for 10-20 minutes once a day for 8 weeks

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients diagnosed with amyotrophic lateral sclerosis (ALS) at Peking University Third Hospital between October 2024 and October 2025, meeting the revised 1998 ALS El Escorial diagnostic criteria; aged 18 to 70 years; FRS-R score > 24; HAMA score = 7 or HAMD score > 7; and who agree to and sign the informed consent form.

Exclusion criteria

Exclusion criteria: Patients with a history of other central nervous system diseases, such as cerebrovascular disease or Parkinson's syndrome, as well as a history of psychiatric disorders or head trauma; patients with frontotemporal degeneration who are unable to comply with mindfulness intervention; patients concurrently participating in other clinical studies; and those who are unable to comprehend or cooperate with this clinical study.

Design outcomes

Primary

Measure	Time frame
The Amyotrophic Lateral Sclerosis Assessment Questionnaire;Hamilton Depression Scale (HAMD);Hamilton Anxiety Scale (HAMA);Pittsburgh sleep quality index (PSQI);Electroencephalogram (EEG);	—

Secondary

Measure	Time frame
Chinese Perceived Stress Scale (CPSS);Mindful Attention Awareness Scale (MAAS);Zarit Caregiver Burden Interview (ZBI);	—

Countries

China

Contacts

Public ContactWang Liping

Peking University Third Hospital

dianer@126.com+86 10 8226 5694

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026