Macrolide-unresponsive Mycoplasma pneumoniae pneumonia
Conditions
Interventions
Glucocorticoid group:2mg/kg/day methylprednisolone sodium succinate intravenous drip
Doxycycline group:Doxycycline 2 mg/kg orally every 12 hours
Sponsors
Xi'an Children's Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: Definition of macrolide-unresponsive Mycoplasma pneumoniae pneumonia (MUMPP): MPP patients who meet the diagnostic criteria continue to have fever (axillary temperature = 37.5°C) after 72 hours of regular treatment with macrolide antibiotics (oral or intravenous administration), and their clinical signs and lung imaging do not improve or further worsen.
Exclusion criteria
Exclusion criteria: 1. Use of steroid hormones or immunomodulators such as immunoglobulin before admission; 2. Use of tetracyclines or quinolones before admission; 3. Combination of other autoimmune diseases; 4. Combination of genetic metabolic diseases, blood tumor diseases, etc. (such as cystic fibrosis, primary ciliary dyskinesia, etc., children may have immune system dysfunction); 5. Children with primary or secondary immunodeficiency diseases; 6. Combination of other respiratory pathogen infections.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of subjects whose fever subsided or whose body temperature dropped significantly within 48 hours after intervention measures; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of people who need to combine two treatment options;Number of people requiring IVIG treatment;Number of bronchoscopies required;Number of people who developed mixed infections after treatment (such as mixed bacterial and viral infections);Length of hospital stay;Hospitalization expenses;Chest imaging absorption at discharge;Number of patients with sequelae after 3 months of follow-up; | — |
Countries
China
Contacts
Public ContactXinrong Sun
Xi'an Children's Hospital
Outcome results
None listed