Clostridioides Difficile Infection
Conditions
Interventions
Treatment Group:Oral Rifaximin (for children aged 3 to under 12 years: 200mg orally, three times a day for 10 days
for children aged 12 to under 18 years: 550mg orally, three times a day for 10 days).
Control Group:Vancomycin 40mg/kg/day orally, every 6 hours (maximum dose per dose 125mg) for 10 days.
Sponsors
Chilren's Hospital of Shanghai
Eligibility
Sex/Gender
All
Age
3 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Age: 3 years = age < 18 years; more than 3 episodes of diarrhea per day, with Bristol stool type 6-7, and laboratory tests positive for Clostridioides difficile; 2. Laboratory stool examination is positive for Clostridioides difficile (toxin A/B); 3.The legal guardian fully understands and signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Concurrent with other severe gastrointestinal diseases; 2.Concurrent with other severe systemic diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diarrhea;Clostridioides difficile Toxin A/B Negative; | — |
Countries
China
Contacts
Public ContactXiaolu Li
Chilren's Hospital of Shanghai
Outcome results
None listed