Alzheimer's disease
Conditions
Interventions
Sevoflurane Group :In the sevoflurane group, intraoperative anesthesia maintenance was achieved using sevoflurane inhalation anesthesia.
Propofol Group:In the propofol group, intraoperative anesthesia maintenance was performed using propofol.
Sponsors
The First People's Hospital of Zunyi
Eligibility
Sex/Gender
All
Age
50 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) Meet the clinical diagnostic criteria and symptom staging standards for Alzheimer's disease (AD); (2) Participants must be >50 years old; (3) Disease duration must be >6 months; (4) Clinical Dementia Rating (CDR) scale score must be 2 or 3, indicating moderate or severe dementia; (5) Mini-Mental State Examination (MMSE) score must be 10-15, with accompanying Behavioral and Psychological Symptoms of Dementia (BPSD); (6) No history of psychiatric disorders or epilepsy, and no other severe organ or systemic diseases; (7) American Society of Anesthesiologists (ASA) physical status classification =2; (8) Undergoing LVA surgery under general anesthesia with intubation; (9) Patients and their families have been thoroughly informed about the purpose, significance, expected outcomes, and potential risks of the study and have voluntarily agreed to participate, signing the relevant informed consent forms.
Exclusion criteria
Exclusion criteria: (1) Patients with non-AD or mild AD; (2) Patients with other mental disorders or cognitive impairment due to depression, Parkinson's disease, stroke, etc.; (3) Patients with critical illness (preoperative ASA physical status classification > 3), severe liver dysfunction (Child-Pugh class C), or severe renal insufficiency (preoperative dialysis); (4) Patients who cannot tolerate cervical lymph node-vein anastomosis surgery; (5) Patients with a family history or personal history of malignant hyperthermia, and those with contraindications to sevoflurane or propofol use.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A-ß;P-tau;MRI;MMSE;ADAS-cog;ADL; | — |
Countries
China
Contacts
Public ContactZhang Jing
The First People's Hospital of Zunyi
Outcome results
None listed