Liver cancer, hepatic hemangioma, cholangiocarcinoma and others
Conditions
Interventions
Milrinone and Teripressin group:After implantation of a double-lumen central venous catheter, Milrinone (12.5ug/kg,10min, i.e. 0.3ml/kg/h,10min) combined with terlipressin (1mg,10min, i.e. 120ml/h,10m
Saline solution group:After the two-cavity central venous catheter was inserted, normal saline (0.3ml/kg/h,10min) combined with normal saline (120ml/h,10min) was pumped, and then normal saline (0.12ml
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) American Society of Anesthesiologists (ASA) Level I-III (2)Age >=18 years old (3) Body mass index (weight divided by height squared) 18~30kg/? (4) Selective liver resection under general anesthesia (hepatectomy refers to the removal of local lesions of the liver due to primary or secondary malignant tumors or benign tumors; the surgical method is open or laparoscopic) (5) Those who can understand and sign the informed consent form
Exclusion criteria
Exclusion criteria: (1) Patients with portal hypertension before surgery (ascites, splenomegaly, thrombocytopenia with platelets 180/100 mmHg after sedation) (11) Currently participating in another interventional study that may affect the primary outcome
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative blood loss;Incidence of postoperative acute kidney injury; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood transfusion volume;leukocyte;C-reactive protein;platelet;albumin;Hypersensitive troponin;Brain natriuretic peptide;Serum creatinine;Cystatin C;Mean arterial pressure;Heart rate;Central venous pressure;Duration of hypotension;Vasoactive drug use;Minimum central venous pressure;Lactic acid maximum;Infusion volume;Urine volume;Drug-related adverse events;Time of first feeding;First exhaust time;Time of first defecation;Length of stay;Postoperative complication; | — |
Countries
China
Contacts
Public ContactYueying Zhang
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed