pain
Conditions
Interventions
oxycodone group:After tracheal intubation and mechanical ventilation, immediate sedative and analgesic treatment was performed. The initial plan was for the study group to receive intravenous infusion
Remifentanil group:After tracheal intubation and mechanical ventilation, immediate sedative and analgesic treatment was performed. The initial plan was for the study group to receive intravenous infus
Sponsors
Affiliated Hospital of North Sichuan Medical College
Eligibility
Sex/Gender
All
Age
19 Years to 89 Years
Inclusion criteria
Inclusion criteria: (1) Age>18 years old,24 hours;
Exclusion criteria
Exclusion criteria: (1) Stay in the ICU for at least 1 week before enrollment; (2) Having symptoms of drug use, delirium, alcohol withdrawal, or mental illness, or using antipsychotic drugs; (3) Study drug allergies or other contraindications; (4) Severe renal insufficiency combined with blood purification treatment is necessary; (5) Combined severe liver dysfunction (Child Pugh grade C); (6) Comatose patients (GCS score<8 points); (7) Severe hypotension requiring high-dose vasoactive drugs to maintain blood pressure; (8) The patient or authorized client of the patient does not agree to participate in the study; (9) Pregnant or lactating women; (10) Deep sedation is required (oxygenation index = 100mmHg, loss of consciousness during muscle relaxant treatment, status epilepticus, absolute immobilization required for surgical or surgical conditions, severe traumatic brain injury with intracranial hypertension, therapeutic hypothermia, and other clinical evaluations requiring maintenance of RASS score<-2 points); (11) According to the condition, it is expected that mechanical ventilation support will be required for a long time, such as peripheral neuromuscular diseases, brainstem injuries, and respiratory center involvement.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| heart rate;mean arterial pressure;Translate Vasoactive drug dosage Vasoactive drug dosage;Respiratory rate;Oxygenation index;Platform pressure;airway peak pressure;airway resistance ;Static compliance;Respiratory work; | — |
Secondary
| Measure | Time frame |
|---|---|
| Average hourly dose of analgesics to achieve analgesic goals;Average sedative dose per hour to achieve sedative goals;Mechanical ventilation time;ICU hospitalization time;Adverse reaction incidence rate; | — |
Countries
China
Contacts
Public ContactChen Li
Affiliated Hospital of North Sichuan Medical College
Outcome results
None listed