impacted teeth
Conditions
Interventions
Antibacterial drug group:Amoxicillin
Non steroidal drug group:Celecoxib
Control group:placebo
Sponsors
People's Liberation Army Joint Logistics Force No. 901 Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18-50 years old; 2. No history of heart or lung disease, liver or kidney disease, abnormal bleeding, or coagulation dysfunction; 3. Not taking painkillers, anti-inflammatory drugs, or anticoagulants for one week before tooth extraction; 4. Pell and Gregory classification of mandibular mesial impacted third molars; 5.The surgery is expected to be completed within 15-30 minutes; 6. The patient is willing to participate in this study and fill out the survey questionnaire. 7. There was no acute inflammation around the crown before surgery, and the adjacent teeth were healthy.
Exclusion criteria
Exclusion criteria: 1. Pregnant, menstruating, or lactating women; 2. Complicated with acute oral infectious diseases or tumor; 3. Have a history of allergies to the medication used in this study; 4. Suffering from chronic pulpitis, chronic periapical periodontitis, trigeminal neuralgia, glossopharyngeal neuralgia and other pain related diseases that have not been treated or require long-term use of other analgesics; 5. The patient drank alcohol within one week before surgery; 6. Individuals with a history of upper gastrointestinal bleeding or perforation related to the use of nonsteroidal anti-inflammatory drugs in the past; 7. Patients with active or previous history of peptic ulcers, gastrointestinal bleeding or perforation; 8. Allergies to other nonsteroidal anti-inflammatory drugs; 9. Asthma patients who are allergic to aspirin; 10. Currently taking other drugs containing ibuprofen or other nonsteroidal anti-inflammatory drugs, including drugs known to be specific cyclooxygenase-2 inhibitors; 11. Patients with intellectual, visual, hearing, or communication impairments or those deemed unsuitable by researchers to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analogue Score;Postoperative inflammatory complications;Postoperative swelling ; restricted mouth opening;Postoperative bleeding;Pre pharyngeal reaction;Gastrointestinal reactions;ulcer;heating;Postoperative Reaction Severity Scale for Tooth Extraction; | — |
Countries
China
Contacts
Public Contactxin wang
People's Liberation Army Joint Logistics Force No. 901 Hospital
Outcome results
None listed