Adolescent large bone age short stature
Conditions
Interventions
Group A: Starting GnRHa combined with growth hormone:None
Group B: Initial monotherapy with GnRHa, followed by the addition of growth hormone when the growth rate decreases:None
Sponsors
Yiwu Maternity and Children Hospital
Eligibility
Sex/Gender
All
Age
8 Years to 15 Years
Inclusion criteria
Inclusion criteria: 1. Initial treatment age: girls CA > 8 years, boys > 9 years, Tanner (stage II-III); 2. Bone age less than 13 years (girls) or less than 14 years (boys); 3. Legal guardians and the individual agree to participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: If any of the following criteria are met, the individual must be excluded from this study: 1. Abnormal liver or kidney function. 2. History of hepatitis B or C, or known active hepatitis B or C. 3. Currently diagnosed or previously diagnosed with malignant tumors; 4. Confirmed to have other types of growth and development abnormalities, such as idiopathic short stature, Turner syndrome, Noonan syndrome, Laron syndrome, growth hormone receptor deficiency, small for gestational age with short stature, growth and development delay due to malnutrition, growth and development delay due to hypothyroidism, etc.; 5. Congenital skeletal developmental abnormalities or scoliosis (scoliosis angle =15 degrees, or moderate to severe scoliosis requiring treatment), limping; 6. Diagnosed with diabetes, or fasting blood glucose =126mg/dL (7.0mmol/L) or glycated hemoglobin (HbA1c) =6.5% at screening; 7. Participated in any other clinical study within 3 months prior to screening and has received drug or non-drug interventions; 8. Other conditions that the investigator deems unsuitable for inclusion in this clinical study.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| ?GV;?Ht SDS;Adverse reaction; | — |
Primary
| Measure | Time frame |
|---|---|
| ?PAH; | — |
Countries
China
Contacts
Public ContactCAO XUYING
Yiwu Maternity and Children Hospital
Outcome results
None listed