Postoperative Pain
Conditions
Interventions
Oliceridine group (O group):Patient-controlled intravenous analgesia with oliceridine
Sufentanil group (C group):Patient-controlled intravenous analgesia with sufentanil
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing allogeneic renal transplantation surgery at our hospital (usually emergency and open-abdomen surgery) with an unlimited duration of surgery; 2. Age 18-65 years old, gender is not limited; 3. 18kg/m^2<BMI<30kg/m^2; 4. Those who are fully informed of the relevant content of the clinical trial, voluntarily join and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients undergoing multi-organ transplantation surgery; 2. Previous history of other organ transplantation surgery; 3. Patients who underwent unplanned secondary surgery after kidney transplantation; 4. Patients with severe diseases, such as chronic liver disease and cardiac insufficiency; 5. Those who have a history of alcohol abuse within the previous 2 years, that is, those who drink more than 14 units of alcohol per week (360mL beer/45mL alcohol with a 40% alcohol content/150mL wine with a 1 unit alcohol content) or have acute alcohol intoxication or alcohol dependence; 6. Patients with a history of opioid allergy or long-term oral opioid use; 7. History of severe postoperative nausea and vomiting; 8. History of mental illness such as schizophrenia; 9. Those who are judged to lack the ability to give informed consent or fail to sign the informed consent; 10. Patients who refused to participate further during the follow-up period;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The effective rate of PCIA analgesia in 24h after operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS scores and cumulative AUC at 6 time points within 48 hours after surgery, maximum pain intensity within 48 hours, first PCA time, number of effective PCA compressions, and dosage of remedial analgesics;The incidence of opioid-related adverse complications (dizziness, drowsiness, nausea, vomiting, respiratory depression, hypoxemia, etc.) within 48 hours after surgery;The use of antiemetic drugs within 48 hours after surgery;Satisfaction with analgesia at 48h after surgery;Changes in renal function evaluation, inflammatory factors, and postoperative immune indicators 7 days after surgery;Quality of recovery at 1 day and 3 days after surgery; | — |
Countries
China
Contacts
Public ContactYaomin Zhu
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed