Insulin resistant, PCOS
Conditions
Interventions
Group A:The antagonist protocol will be used as the control ovarian hyperstimulation protocol in this trial. Patients will be administered the initial dose of rFSH with 75-112.5IU.
Group B:The antagonist protocol will be used as the control ovarian hyperstimulation protocol in this trial. Patients will be administered the initial dose of rFSH with 150IU.
Group C:The antagonist protocol will be used as the control ovarian hyperstimulation protocol in this trial. Patients will be administered the initial dose of rFSH with 187.5-225IU.
Sponsors
Guangdong Provincial People's Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: ?Women aged 20-40; ?Diagnosed with PCOS according to Rotterdam criteria; ?=2 IVF/ICSI control ovarian hyperstimulation cycles; ?HOMA-IR =2.5.
Exclusion criteria
Exclusion criteria: ?History of recurrent miscarriage; ?Untreated uterine malformation or abnormality: dual uterus, septate uterus (complete or incomplete), moderate to severe intrauterine adhesions, etc.; ?Preimplantation genetic screening required; ?Severe liver or kidney dysfunction; ?Patients with other serious organ system diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate for first embryo transfer cycle; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ovarian sensitivity index;Number of oocytes retrived;Incidence of moderate to severe OHSS;Number of high-quality embryos;Persistent pregnancy rate;Early abortion rate; | — |
Countries
China
Contacts
Public ContactXie Yanqiu
Guangdong Provincial People's Hospital
Outcome results
None listed