motor neuron disease (MND)
Conditions
Interventions
Experimental Group:Subjects operated a computer using a wearable non-invasive brain-computer interface mouse system for 10 days, once a day for no less than 15 minutes
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients diagnosed with motor neuron disease (MND) at Peking University Third Hospital between October 2024 and October 2025, meeting the revised 1998 ALS El Escorial diagnostic criteria; aged 18 to 70 years; with an FRS-R score greater than 24 (with upper limb function score = 4, corresponding to items 4-7 on the scale); and who agree to and sign the informed consent form.
Exclusion criteria
Exclusion criteria: Patients with a history of other central nervous system diseases, such as cerebrovascular disease or Parkinson's syndrome, as well as a history of psychiatric disorders or head trauma; patients with frontotemporal degeneration who are unable to cooperate with the use of the equipment; patients concurrently participating in other clinical studies; and those who are unable to comprehend or cooperate with this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the MOS item short from health survey (SF-36);The amyotrophic lateral sclerosis assessment questionnaire (ALSAQ-40); | — |
Secondary
| Measure | Time frame |
|---|---|
| Self-Depression Scale;Patient Activation Measure 13;Self-Rating Anxiety Scale (SAS);Zarit Burden Interview (ZBI);NASA Task Load Index (NASA-TLX); | — |
Countries
China
Contacts
Public ContactWang Liping
Peking University Third Hospital
Outcome results
None listed