Parkinson's disease
Conditions
Interventions
Healthy control group:None
Sponsors
Guangdong Provincial People’s Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for Parkinson's disease group: 1. Patients with primary Parkinson's disease diagnosed by two or more senior neurologists according to the MDS diagnostic criteria 2. Age: 40-80 years old, the first motor symptoms appeared after 40 years old 3. Participants and their families fully understood and signed the informed consent form Inclusion criteria for healthy control group: 1. Global cognitive assessment: MMSE = 26, MoCA = 24 2. Age: 40 - 80 years old 3. Able to complete a comprehensive neuropsychological assessment without self-reported cognitive decline 4. Participants and their families fully understood and signed the informed consent form
Exclusion criteria
Exclusion criteria: Exclusion criteria for Parkinson's disease group: 1. Use of anticholinergic drugs 2. Clinically significant lesions found in previous cranial MRI or EEG scans 3. Schizophrenia, delirium or hallucinations that affect clinical evaluation 4. After deep brain stimulation surgery 5. Combined autoimmune or infectious diseases and other medical diseases that affect clinical evaluation Exclusion criteria for healthy control group: 1. Abnormal cognitive function (MMSE < 26, MoCA < 24) 2. Clinically significant lesions found in previous MRI or EEG scans 3. Combined schizophrenia, delirium or hallucinations 4. Previous brain surgery or severe trauma 5. Recent use of cholinesterase inhibitors or other drugs 6. Autoimmune or infectious diseases 7. The patient or his/her immediate family members are diagnosed with neurodegenerative diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| inflammatory protein in body fluid;the change of brain stucture; | — |
Secondary
| Measure | Time frame |
|---|---|
| Eye movement indicators;24-hour ambulatory blood pressure;Gait assessment;the change of fundus oculi; | — |
Countries
China
Contacts
Public ContactYuhu Zhang
Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences)
Outcome results
None listed