postoperative pain
Conditions
Interventions
first:Mix 0.5mg/10ml fentanyl with 90ml physiological saline to 100ml. The loading amount is 4ml, followed by a patient-controlled analgesia regimen with a PCA dose of 2ml, a locking time of 6 minutes
second:Mix 10mg/10ml oliceridine with 90ml physiological saline to 100ml. Divide the load into two doses, 0.75 mg each time and a total of 1.5 mg, with a 10 minute interval between each dose
Afterwards, a patient-controlled analgesia plan was developed, with a PCA dose of 0.2mg or 2ml, a locking time of 6 minutes, and no background dose
third:Mix 10mg/10ml oliceridine with 90ml physiological saline to 100ml. Divide the load into two doses, 0.75 mg each time and a total of 1.5 mg, with a 10 minute interval between each dose
Afterwards, a patient-controlled analgesia plan was developed, with a PCA dose of 0.35mg or 3.5ml, a locking time of 6 minutes, and no background dose
Sponsors
People's Hospital of Tianjin
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Age range of 65-80 years old; 2) ASA levels I-III; 3) BMI 18.5-24.9; 4) Planned surgery for lower abdominal colorectal cancer under general anesthesia; 5) Accept postoperative patient-controlled intravenous analgesia pump (PCIA) treatment; 6) Having the ability to read and write;7) You can sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1) Severe liver and kidney dysfunction; 2) Patients with mental illnesses; 3) METs<4 patients; 4) Abuse of anesthesia and sedatives; 5) History of allergies to relevant drugs; 6) Emergency reoperation; 7) Post operative admission to ICU; 8) Participated in clinical research on other drugs or medical devices in the past 3 months; 9) Those determined by researchers to be ineligible for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS rating; | — |
Secondary
| Measure | Time frame |
|---|---|
| consumption of analgesic drugs;Ramsay Sedation Rating; | — |
Countries
China
Contacts
Public ContactDing Ling
People's Hospital of Tianjin
Outcome results
None listed