Postoperative delirium
Conditions
Interventions
Experimental Group 1:Intranasal insulin administration at a dose of 40 IU per session (0.5 ml), twice daily at 9:00 AM and 7:00 PM.
Experimental Group 2:Intranasal insulin administration at a dose of 20 IU per session (0.5 ml), twice daily at 9:00 AM and 7:00 PM.
Control group:Intranasal administration of 0.9% saline solution (0.5ml) twice a day at 9:00 AM and 7:00 PM.
Sponsors
Zhangzhou Municipal Hospital, Fujian Province
Eligibility
Sex/Gender
All
Age
60 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age = 60 years 2. American Society of Anesthesiologists (ASA) classification of physical status I-III 3. Diagnosed with traumatic hip fracture upon admission 4. Capable of accurately understanding the Mini-Mental State Examination (MMSE), with an admission MMSE score greater than 23.
Exclusion criteria
Exclusion criteria: 1. Contraindications to intranasal administration, such as nasal defects or lesions 2. History of insulin allergy 3. History of alcohol abuse 4. Inability to communicate prior to surgery, due to conditions such as coma, severe dementia, language disorders, or significant visual or auditory impairments 5. Long-term use of antidepressants or sedatives 6. Presence of systemic diseases that affect cerebrospinal fluid biomarker levels 7. Contraindications to spinal anesthesia puncture 8. History of neurological or psychiatric disorders 9. Presence of delirium or subsyndromal delirium upon admission.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Concentrations of insulin in cerebrospinal fluid;Aß42 in cerebrospinal fluid.;total tau protein (t-tau) in cerebrospinal fluid;phosphorylated tau protein (p-tau) in cerebrospinal fluid;Plasma tau protein;CAM-CR delirium score;Serum insulin;fasting blood glucose; | — |
Countries
China
Contacts
Public ContactWang Chuting
Zhangzhou Municipal Hospital, Fujian Province
Outcome results
None listed