depressive disorder
Conditions
Interventions
Individualised vmPFC, AMG TMS treatment group:Individualised TMS treatment with vmPFC, AMG as deep effector brain regions
Individualised sgACC TMS treatment group:Individualised TMS treatment with sgACC as a deep effector brain region
5cm positioning TMS treatment group:Traditional 5cm positioning method TMS treatment
Sponsors
The Third Hospital of Inner Mongolia Autonomous Region
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. be aged 18-65 years and have signed an informed consent form; 2. have adequate comprehension and =9 years of cultural education; 3. Han Chinese, right-handed; 4. meet the diagnostic criteria for depressive disorders in the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) and pass the DSM-5 Definitive Clinical Examination of Disorders (SCID-5) screening; 5. have a total HAMD-17 score of =17.
Exclusion criteria
Exclusion criteria: 1. Excluding those with severe cardiac, hepatic and renal insufficiency; and 2. exclude schizophrenia spectrum and other psychotic disorders, bipolar and related disorders, neurocognitive disorders, substance-related and addictive disorders, and other psychiatric disorders caused by physical illnesses or medications, as well as serious suicidal tendencies; 3. have recently received physiotherapy, such as rTMS, DBS, etc.; or have been treated by a physiotherapist. 3. Recent physical therapy such as rTMS, DBS, etc. 4. pregnant women or women = 6 months after delivery or breastfeeding; and 5. Inability to read and understand the information sheet and the informed consent form or the patient self-assessment scale. 6. Participating in other clinical trials. 7. History of traumatic brain injury or organic brain disease. 8. Patients with metallic or electronic devices, such as cochlear implants, pacemakers, stents, or other metallic foreign objects in their bodies; and 9. Patients with seizure risk or other contraindications to cranial MRI and TMS.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in 24-Hamilton Depression Scale before and after treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in Hamilton anxiety scale before and after treatment;Changes in the Montgomery-Eisenberg Depression Rating Scale before and after treatment;Changes in the 9-item Patient Health Questionnaire before and after treatment;Changes in the Snaith-Hamilton Pleasure Scale before and after treatment;Change in Beck Depression Questionnaire before and after treatment;Changes in Rumination Thinking Scale before and after treatment;Treatment Emergent Symptom Scale post-treatment scores;Changes in the Pittsburgh Sleep Quality Index Scale before and after treatment;Change in insomnia severity index scale before and after treatment;Changes in functional connectivity before and after treatment;Changes in local activity indicators before and after treatment; | — |
Countries
China
Contacts
Public ContactDongsheng Lv
The Third Hospital of Inner Mongolia Autonomous Region
Outcome results
None listed