Parkinson's disease
Conditions
Interventions
Propofol group :propofol is used for anesthesia induction and maintenance
Remimazolam group:Remimazolam is used for anesthesia induction and maintenance
Sponsors
The First Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
40 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Primary Parkinson's disease patients undergoing bilateral subthalamic nucleus deep brain electrode implantation under general anesthesia; (2) No previous history of brain surgery; (3) Patients without intracranial hemorrhage during surgery; (4) Age between 40-65 years old.
Exclusion criteria
Exclusion criteria: (1) There is significant cognitive impairment (MOCA score<10); (2) Serious anxiety, depression, suicidal behavior or tendencies, significant mental disorders and other mental illnesses that are difficult to treat with medication; (3) Combine diagnosed hypertension, cardiovascular and cerebrovascular diseases, peripheral vascular diseases, arrhythmia, moderate to severe liver dysfunction (child gauge grade B or C), and moderate to severe renal dysfunction (glomerular filtration rate<90ml/min); (4) After 10 minutes of resting in a supine position, the cuff blood pressure is higher than 180/110mmHg; (5) There are contraindications for propofol or remifentanil drugs; (6) Alcoholics; (7) Those who refuse to undergo general anesthesia or refuse to sign informed consent forms; (8) The researchers believe that it is not appropriate for them to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The average length recorded by subthalamic nucleus microelectrodes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative blood pressure variability;Dosage of anesthetics and vasoactive drugs;Surgical time;Improvement rate of postoperative movement disorders; | — |
Countries
China
Contacts
Public ContactNan Jiang
The First Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed