Postoperative pain in patients undergoing gastrointestinal surgery
Conditions
Interventions
Group L:Use of low background doses of olicerdine for postoperative analgesia
Group M:Use of medium background doses of olicerdine for postoperative analgesia
Group H:Use of high background doses of olicerdine for postoperative analgesia
Group C: Use of sufentanil for postoperative analgesia
Sponsors
Dazhou Central Hospital
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients selected for gastrointestinal surgery under general anesthesia, aged 30-70 years old, BMI 18-35 kg/m2, ASA grade II-III, signed informed consent and postoperative analgesia consent
Exclusion criteria
Exclusion criteria: People with mental illness and language communication disorder; Patients with severe hepatic and renal dysfunction that may affect drug metabolism; Pregnant or nursing patients; A history of opioid allergy; A history of chronic pain, long-term use of chronic opioid therapy or psychotropic drugs; Use of drugs that may affect the analgesic response (central alpha-adrenergics, antiepileptics, neurosuppressors, antidepressants, or antipsychotics) and not stable for =30 days prior to use
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score;Total number of analgesic pump compressions and effective compressions; Postoperative analgesic dose; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of postoperative respiratory depression;Incidence of postoperative nausea and vomiting;Postoperative Ramsay Sedation Score;Postoperative inflammatory factor levels; | — |
Countries
China
Contacts
Public ContactXuping Hu
Dazhou Central Hospital
Outcome results
None listed