tumors of liver
Conditions
Interventions
Hyperoxia group:After anesthesia induction, the fraction of inspired oxygen (FiO2) is 80%.
Hypoxia group:After anesthesia induction, the fraction of inspired oxygen (FiO2) is 30%.
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Participants who are scheduled to undergo liver resection under sevoflurane inhalation general anesthesia at Huashan Hospital Affiliated to Fudan University from November 2024 to October 2025 were included. 1) Age = 18 years and 2 hours (defined as from the induction of anesthesia to the completion of wound suture). 4) Voluntary participation in the trial and signing of the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Severe cardiopulmonary diseases and myocardial infarction within 3 months. 2) Pregnant or lactating women. 3) Moderate to severe obstructive sleep apnea syndrome. 4) ASA = grade IV, with decompensated severe liver or kidney diseases. 5) Planned to be admitted to the ICU after surgery. 6) Preoperative peripheral blood oxygen saturation (SpO2) lower than 90%, or chronic obstructive pulmonary disease [PaO2 < 60 mmHg]. 7) Participating in other clinical studies concurrently. 8) Those with allergy or contraindications to conventional anesthetic drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clavien-Dindo classification; | — |
Secondary
| Measure | Time frame |
|---|---|
| Oxidative stress indices;inflammatory markers;liver and kidney functions;coagulation parameters; | — |
Countries
China
Contacts
Public ContactYingwei Wang
Huashan Hospital, Fudan University
Outcome results
None listed