metabolism-associated fatty liver disease
Conditions
Interventions
Sponsors
Zhejiang Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18-65 years, male or female; 2.Diagnosis of hepatic steatosis by imaging (including ultrasound, MRI or FibroScan) or liver histology; 3.Informed and signed consent to participate in this study.
Exclusion criteria
Exclusion criteria: 1. Pregnant and lactating women; 2. Combined with other liver diseases, such as drug-induced hepatitis, autoimmune liver disease, alcoholic liver disease, chronic hepatitis C, hepatomegaly, autoimmune liver disease and other liver diseases, and end-stage liver disease; 3. Combined with infectious diseases, such as viral hepatitis, tuberculosis, AIDS, etc.; 4. Excessive alcohol consumption; 5. Drugs such as tamoxifen, etamivir, methotrexate, sodium valproate, and glucocorticoids and other drugs; 6. Combined with other serious systemic diseases, such as coronary heart disease, heart failure, stroke, renal insufficiency, tumour, serious infections, etc.; 7. Major surgery or major stressful events in the past 2 months; 8. Weight fluctuation of more than 5% of one's own body weight in the past 3 months; 9. Taking drugs that cause liver injury in the past 3 months; 10. Taking drugs to treat steatohepatopathy or to correct metabolic disorders in the past 3 months. metabolic disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRI-PDFF; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fatty Liver Index;Triglycerides;Total cholesterol;High density lipoprotein cholesterol (HDL);Low density lipoprotein cholesterol (LDL);Non high density lipoprotein cholesterol;Small and dense low-density lipoprotein cholesterol;Lipoproteins;Serum free fatty acids;Lipoprotein associated phospholipase A2;Apolipoprotein A;Apolipoprotein B;Alanine aminotransferase;Aspartate transaminase;Bilirubin value;body mass index;Waist;Relative changes in patient weight before and after treatment (%);Body fat;visceral fat mass;Traditional Chinese Medicine Syndrome Score;Tongue image parameters;Pulse diagnosis parameters; | — |
Countries
China
Contacts
Public ContactYuqun Cai
Zhejiang Provincial People's Hospital
Outcome results
None listed