recurrent pregnancy loss
Conditions
Interventions
Study group:According to the current routine treatment of recurrent abortion, the study group was given the corresponding treatment, at the same time, vitamin D drops were given 2000IU /d. 25-hydroxyv
Control group:The control group was given the corresponding treatment according to the current routine of recurrent abortion, and was given 400IU /d vitamin D drops until 28 weeks of pregnancy or anot
Sponsors
Shanghai First Maternity and Infant Hospital
Eligibility
Sex/Gender
Female
Age
19 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1) Aged 19 - 40years 2) Two or more miscarriages with the 28th gestational week 3) peripheral blood 25-hydroxyvitamin D level <30ng/L (75nmol/L) 4) Planning to be pregnant or pregnancy within 7 gestational weeks 5) Voluntarily participating in this study and signing an informed consent form.
Exclusion criteria
Exclusion criteria: 1) Parental karyotype abnormalities (Chromosomal balanced translocation or Robertsonian translocations) 2) Genital tract abnormalities 3) Combine hyperprolactinemia that has not been treated, thyroid dysfunction that has not been treated, poorly controlled diabetes, and uncontrolled hypertension that has not been treated according to guidelines. 4) Serious primary diseases of liver, kidney, heart, lung and other organs are not suitable for pregnancy or other pregnancy contraindication5) Patients with kidney stones, chronic constipation 4) Allergy to vitamin D preparations
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Spontaneous Abortion rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Gestational diabetes mellitus ;Preeclampsia;preterm birth; small for geatational age;Iive birth rate; | — |
Countries
China
Contacts
Public ContactGuohua Li
Shanghai First Maternity and Infant Hospital,
Outcome results
None listed