Hypertension
Conditions
Interventions
Group A (Amlodipine besylate and benazepril hydrochloride):Amlodipine besylate and benazepril hydrochloride tablet 1 tablet per day
Group A (Amlodipine and Bisoprolol):Amlodipine and Bisoprolo tablet 1 tablet per day
Sponsors
Shaoxing Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Over 18 years old; 2. Meets the "WHO/ISH" diagnostic criteria for hypertension; 3. The patient agrees to sign an informed consent form; 4. Clinical conditions require drug combination therapy; 5. Having characteristics of arteriosclerosis, including: 1) Carotid atherosclerosis: Carotid ultrasound IMT = 0.9mm or atherosclerotic plaque; Carotid artery stenosis; History of carotid artery revascularization; 2) Arteriosclerosis of lower limbs: arterial plaque of lower limbs or ankle brachial index<0.9; Lower limb arterial stenosis; History of lower limb revascularization; 3) Aortic syndrome: aortic atherosclerosis; Aortic intramural hematoma; Local aortic ulcer; 4) Coronary atherosclerosis or coronary heart disease: coronary artery plaque or even stenosis is found by coronary artery CT or coronary angiography; Have a history of myocardial infarction or typical angina pectoris; Have a history of coronary artery revascularization. 5) History of stroke or TIA: including ischemic stroke and TIA; 6) Fundus arteriosclerosis: Scheie grade 2 or above in the fundus;
Exclusion criteria
Exclusion criteria: 1. Secondary hypertension; 2. Severe cardiovascular and cerebrovascular diseases; 3. Severe liver and kidney dysfunction; 4. History of allergies or significant adverse reactions to experimental or observation group drugs; 5. Known malignant tumors, severe hematological disorders, or active rheumatism.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Morning BP;Ambulatory blood pressure; | — |
Countries
China
Contacts
Public ContactJianyao Shen
Shaoxing Central Hospital (The Central Affiliated Hospital, Shaoxing University)
Outcome results
None listed