Minimal hepatic encephalopathy
Conditions
Interventions
Treatment group:1.Pre-treatment gut preparation:the patient will receive three days of oral Vancomycin and gentamicin for intestinal elution, then they will be treated with fecal microbiota transplant
Control Group:The patient will receive three days of oral Vancomycin and gentamicin for intestinal elution, then they will take empty capsules without fecal bacteria.The course of empty capsules is 4
Sponsors
The Affiliated Hospital of Qingdao University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.According to the 2019 Guidelines for the Diagnosis and Treatment of Cirrhosis, the patient was diagnosed with cirrhosis through imaging or histopathology, and the subject was a fully civil person who was capable of understanding the characteristics of the clinical trial; 2. Patients are assessed for MHE using Number connection test, Digit symbol test and brain magnetic resonance, in which any two tests are abnormal and the magnetic resonance is abnormal can diagnose MHE.
Exclusion criteria
Exclusion criteria: 1. Patients with brain diseases such as cerebral hemorrhage, cerebral infarction, brain tumor, intracranial infection, epilepsy, etc.; Patients with metabolic encephalopathy such as ketoacidosis, hypoglycemia, renal encephalopathy, and pulmonary encephalopathy; Patients with alcoholic encephalopathy, heavy metal toxic encephalopathy, withdrawal syndrome and other toxic encephalopathy; 2. Patients with a history of psychosis; 3. Patients with overt hepatic encephalopathy; 4. Patients with diabetes, severe cardiopulmonary diseases, renal insufficiency, thyroid diseases, intestinal obstruction and other diseases which are easy to cause gastrointestinal insufficiency; Patients with lactose intolerance; Patients with other extrahepatic diseases which can lead to malnutrition, chronic diarrhea, etc.; Patients with a history of gastrointestinal bleeding within 6 weeks; Patients with persistent active infection; 5. Patients who have undergone abdominal surgery such as gastric and intestinal resection; 6. Patients with hearing and visual impairments who cannot undergo number connection test, digit symbol test; 7. Patients with poor compliance and other factors that may affect the results of this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| psychometric hepatic encephalopathy score,PHES;Microbiological analysis of feces;Blood ammonia;NCT-A;NCT-B;DST; | — |
Countries
China
Contacts
Public ContactBin Cao
The Affiliated Hospital of Qingdao University
Outcome results
None listed