Mild cognitive impairment
Conditions
Interventions
Experimental group (treatment group):Intermittent limb pressure stimulation
Control group (sham treatment group):Intermittent limb pressure stimulation
Sponsors
Xuanwu Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Eligible participants are adults aged 65 to 80 years, inclusive of both sexes; 2.Patients, healthcare professionals, or informants report alterations in cognitive functions, including memory, that have persisted for a period of at least three months. (Documentation of progressive cognitive decline over time, as ascertained through medical records or clinical assessments) ; 3.According to the diagnostic criteria of the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders, it does not meet the cognitive norm or dementia.Diagnostic criteria for dementia: Mini-mental state examination,MMSE) total score >= 20 points (primary school education level) or >= 24 points (junior high school education level and above),and Montreal cognitive assessment scale (MoCA)Total <= 26 points; Clinical Dementia Rating (CDR) <1 point; 4. The patient or family has understood all study content and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Inability to understand the text, comorbid severe physical disability, or any other factor that may preclude completion of the neuropsychological evaluation; 2. Any neoplastic disease (including polycythemia, excluding basal cell carcinoma or squamous cell carcinoma); 3. Clinically significant cardiovascular and cerebrovascular diseases, pulmonary diseases, liver diseases, kidney diseases, autoimmune or inflammatory diseases, metabolic and endocrine disorders, and severe neuropsychiatric diseases, such as AD, FTD, LBD, PD, schizophrenia, severe depression, epilepsy, etc.; 4. History of alcohol or drug abuse; Use of other medications that may affect this study, such as sedatives, anxiolytic drugs, hypnotic drugs, nootropic drugs, cholinergic drugs; 5. Sudden changes in body functions such as falls, syncope or delirium within 30 days; Presence of pressure injury (such as pressure ulcers, etc.) within 30 days; 6. Received physical stimuli such as electricity, magnetism, heat, and force; 7. Cochlear implants, implanted electrodes, pacemakers or metal implants, etc.; 8. Assessment of daily living ability, mental state and social participation ability, or perceptual and communication ability suggests impaired function; 9. Life expectancy< 1 year; 10. Poor compliance, or inability to cooperate with the completion of complete treatment, etc.; 11. In the opinion of the investigator, there is a situation that is not suitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Imaging index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neuroelectrophysiological index;Hematological index;Neurobehavioral score;Any adverse events; | — |
Countries
China
Contacts
Public ContactHaiqing Song
Xuanwu Hospital Capital Medical University
Outcome results
None listed