schizophrenia
Conditions
Interventions
ultra-brief pulse group:ultra-brief pulse modified electroconvulsive therapy
brief pulse group:brief pulse modified electroconvulsive therapy
Sponsors
Nanjing Brain Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1.age 18~55 years, able to understand survey instructions and execute cognitive tests; right-handed; 2.the International Classification of Diseases, Tenth Edition-based diagnosis of schizophrenia; 3.clinically indicated ECT, including the treatment of severe psychomotor excitement or retardation, suicide attempts, aggressive behavior, pharmacotherapy intolerance, and ineffectiveness of antipsychotics, as assessed by two attending doctors; 4.The Brief Psychiatric Rating Scale score = 35; 5.patients who provided written informed consent for participating in the study and publication of case series;
Exclusion criteria
Exclusion criteria: 1.modified electroconvulsive therapy in the last 3 months; 2.drug or alcohol abuse or dependence in the last 6 months; 3.Contraindications for MECT exist, or there are severe physical illnesses such as stroke, heart failure, liver failure, cancer, or immune deficiencies. 4.MECT might impact the treatment efficacy or the participants’ safety; 5.Pregnant or breastfeeding women, or those planning to conceive during the study period. 6.Having metal implants such as dentures, pacemakers, or internal hearing aids. 7.other conditions that investigators considered inappropriate for participation in this trial (for example, participating in other clinical trials);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MATRICS Consensus Cognitive Battery;autobiographical memory test; | — |
Secondary
| Measure | Time frame |
|---|---|
| The Brief Psychiatric Rating Scale score;N-acetyl-aspartate;choline;myo-inositol;creatinine;inducible forms of the enzyme nitric oxide synthase;homocysteine;prolactin; | — |
Countries
China
Contacts
Public ContactYuxiu Sui
Nanjing Brain Hospital
Outcome results
None listed