Asymptomatic Intracranial Arterial Stenosis
Conditions
Interventions
Probucol group:None
Control group:None
Sponsors
West China Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. In accordance with the expert consensus on imaging evaluation of intracranial atherosclerotic stenosis, intracranial large artery stenosis =50% confirmed by CTA, MRA or DSA; 2. 18 = age =80 years old; 3. No previous ischemic stroke or TIA event.
Exclusion criteria
Exclusion criteria: 1. Suspected atrial fibrillation, known prosthetic heart valve, suspected endocarditis, patent foramen ovale and other congenital heart disease; A history of myocardial damage within 30 days before enrollment, including myocardial infarction, myocarditis; 2. Patients with arterial dissection; or have undergone angioplasty/vascular surgery; 3. Known allergy or intolerance to probucol; 4. Ventricular tachycardia, bradycardia, torsades de pointes; Have a prolonged Q-T interval or are taking other medications that may cause a prolonged Q-T interval; 5. History of cardiogenic syncope or unexplained syncope; 6. Hepatic insufficiency or renal insufficiency; (Hepatic insufficiency was defined as an ALT value >2 times the upper limit of normal or an AST value >2 times the upper limit of normal; Renal insufficiency was defined as serum creatinine >1.5 times the upper limit of normal or glomerular filtration rate <50mL/min). 7. It is expected that surgical treatment or intracranial artery stent implantation will be required during the study period, which may require discontinuation of the trial drug; 8. Have participated in or are undergoing a drug or device clinical trial within the past 30 days; 9. Pregnant or lactating women; 10. Inability to understand or comply with the study due to mental disorders, cognitive or emotional disorders or other reasons considered by the researcher to be inappropriate to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| New ischemic stroke events within 1 year; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in the rate of vascular stenosis after 1 year follow-up;All-cause mortality;The change of serum LDL level after 1 year; | — |
Countries
China
Contacts
Public ContactHe Li
West China Hospital, Sichuan University
Outcome results
None listed