Sarcopenia
Conditions
Interventions
Control group:Single administration
Experimental group:Titration administration
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Age = 65 years; (2) ASA classification 1 to 3; (3) Undergoing elective or semi-elective abdominal surgery; (4) Diagnostic criteria for sarcopenia: L3-SMI: < 50 cm²/m² for males, < 39 cm²/m² for females.
Exclusion criteria
Exclusion criteria: (1) Allergy to sugammadex (SUG); (2) Use of medications that affect the metabolism of neuromuscular blocking agents, such as valproate, carbamazepine, phenytoin, quinidine, calcium channel blockers, magnesium, aminoglycoside antibiotics, etc.; (3) Patients unable to undergo neuromuscular monitoring, such as those with central or peripheral neuromuscular diseases; (4) Renal dysfunction: Estimated Glomerular Filtration Rate (eGFR) < 60 ml/min; (5) No severe comorbidities involving major organs such as the heart, lungs, or liver. Cardiac diseases include but are not limited to coronary artery disease, myocardial infarction, heart failure, etc.; pulmonary diseases include but are not limited to chronic obstructive pulmonary disease, pulmonary embolism, severe asthma, etc.; liver diseases include but are not limited to cirrhosis, severe liver insufficiency, liver tumors, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total SUG dose (mg/kg) required for TOFr to recover to =0.9; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time required for TOFr to recover to =0.9;Incidence of postoperative residual neuromuscular blockade (TOFr =0.9 followed by <0.9);Spontaneous recovery rate of TOFr before SUG administration (?TOFr/min);Administration responsiveness: recovery rate of TOFr (?TOFr/min) after administration of SUG, including early recovery rate and late recovery rate;Postoperative PACU recovery, including time to extubation, time to PACU discharge from the operating room;Incidence of postoperative pulmonary complications, e.g., pneumonia, hypoxemia, re- intubation, ventilator support therapy, respiratory failure;Early postoperative recovery: includes the Quality of Recovery Rating Scale-15 (QoR-15) to assess the quality of the patient's early postoperative recovery, time to the first out-of-bed activity, days of hospitalization, and rate of rehospitalization within 7 days; | — |
Countries
China
Contacts
Public ContactQIONG YU
Huashan Hospital, Fudan University
Outcome results
None listed