Gastrointestinal surgery
Conditions
Interventions
Agroup:Propofol 2mg/kg+ Nalbuphine 0.1mg/kg
B group:Propofol + Nabulphine 0.1mg/kg
C group:Propofol + Nabulphine 0.2mg/kg
Sponsors
Anhui Public Health Clinical Center, the First Affiliated Hospital of Anhui medical University North District
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Elderly patients, aged 65-80 years, scheduled for elective painless gastroscopy; 2.Body mass index BMI 18-25kg/m2, ASA II-III; 3.Gender is not limited, voluntary subjects and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Severe dysfunction in cardiopulmonary,liver,kidney and brain; 2. History of allergy to soy, milk, propofol, sufentanil or local anesthetic drugs; 3. History of alcohol abuse or drug dependence; 4. Severe audiovisual impairment or other factors lead to communication difficulties.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Propofol ED50 ;Nabulphine ED50 ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Respiratory depression;Blood pressure, heart rate, pulse oxygen saturation;The propofol injection hurts;Duration of gastroscopy;Total amount of propofol;Recovery time;Orientation recovery time;Adverse events; | — |
Countries
China
Contacts
Public ContactZhao Xianya
Anhui Public Health Clinical Center, the First Affiliated Hospital of Anhui medical University North District
Outcome results
None listed