Mild vascular cognitive impairment
Conditions
Interventions
Control group (sham-tACS group):Transcranial alternating current stimulation
Experimental group (tACS treatment group):Transcranial alternating current stimulation
Sponsors
Xuanwu Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1: Eligible participants are adults aged 65 to 80 years, inclusive of both sexes. 2: Patients, healthcare professionals, or informants report alterations in cognitive functions, including memory, that have persisted for a period of at least three months. (Documentation of progressive cognitive decline over time, as ascertained through medical records or clinical assessments). 3: In accordance with the diagnostic criteria outlined in the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), the individual does not fulfill the criteria for cognitive normality or dementia. However, the capacity for activities of daily living is within the normal range, as evidenced by a Mini-Mental State Examination (MMSE) score of >=20 for individuals with primary education or >=24 for those with junior education or higher, and a Montreal Cognitive Assessment (MoCA) score of 7. 5:Have fully comprehended the details of the research proto;
Exclusion criteria
Exclusion criteria: 1: Unable to understand the article, combined with severe physical disabilities, or any other factors that may hinder the completion of neuropsychological assessments 2: Any tumor disease (including polycythemia, excluding basal cell carcinoma or squamous cell carcinoma) 3: Clinically significant cardiovascular and cerebrovascular diseases, lung diseases, liver diseases, kidney diseases, autoimmune or inflammatory diseases, metabolic and endocrine disorders, as well as serious neurological and psychiatric disorders such as AD, FTD, LBD, PD, schizophrenia, severe depression, epilepsy, etc 4: History of alcohol or drug abuse; Use other drugs that may affect this study, such as sedatives, anti anxiety drugs, hypnotic drugs, cognitive drugs, and cholinergic drugs 5: Sudden changes in bodily functions such as falls, fainting, or delirium within 30 days; Pressure injuries (such as pressure ulcers) within 30 days 6: Received physical stimuli such as electricity, magnetism, heat, and force 7: There are cochlear implants, implanted electrodes, pacemakers or metal implants, etc 8: Assessment of daily living ability, mental state, social participation ability, or sensory perception and communication ability suggests functional impairment 9: Expected lifespan<1 year 10: Poor compliance or inability to cooperate in completing complete treatment, etc 11: The researchers believe that there are situations where it is not appropriate to participate in this study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neurobehavioral score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neuroelectrophysiological index;Imaging index;Any adverse events; | — |
Countries
China
Contacts
Public ContactHaiqing Song
Xuanwu Hospital Capital Medical University
Outcome results
None listed