Major depressive disorder
Conditions
Interventions
sham tACS+ working memory training:Sham transcranial alternating current stimulation combined with working memory training
active 6Hz tACS+ working memory training:6 Hz transcranial alternating current stimulation combined with working memory training
active 40Hz tACS+ working memory training,:40 Hz transcranial alternating current stimulation combined with working memory training
Sponsors
Institute for Brain Research and Rehabilitation
Eligibility
Sex/Gender
All
Age
12 Years to 21 Years
Inclusion criteria
Inclusion criteria: 1. Age 12-21 years, normal hearing and hearing, right-handed; 2. Unipolar, non-psychotic depression diagnosed by a psychiatrist (meeting DSM-V. diagnostic criteria for depression); 3. Hamilton Depression Rating Scale (HAMD-17) =17 and low suicide risk (suicide item score <3) in this trial; 4. No other physical therapy (electroconvulsive, transcranial magnetic stimulation, etc.) within 6 months; 5. The patient and his family agree to participate in the study;
Exclusion criteria
Exclusion criteria: 1. Have serious suicidal or self-injurious behavior; 2. Have neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, etc.; 3. Combined with serious physical, infectious and immune system diseases; 4. History of organic brain diseases, brain trauma or surgery, and history of seizures; 5. Those who have drug dependence or alcohol dependence within one year;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The outcome of the Brief State Rumination Inventory;Heart rate variability;Reaction time and accuracy of working memory task; | — |
Secondary
| Measure | Time frame |
|---|---|
| The outcome of Beck Depression Inventory-II (BDI-II); | — |
Countries
China
Contacts
Public ContactLijuan Huo
Institute for Brain Research and Rehabilitation
Outcome results
None listed