Treatment-resistant depression (TRD)
Conditions
Interventions
iTBS+cTBS combined cross sequential group:iTBS combined with cTBS cross sequential intervention
Sponsors
Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Being 18 to 60 years of age; 2.Patients who experience a non-psychotic major depressive episode, as defined by the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), and have moderate to severe treatment resistance levels as measured by the Maudsley Staging method (MSM); 3.Patients with poor or no response to adequate doses or courses of treatment with at least two antidepressants with different mechanisms of action; 4.A total HAMD-24 score of >20; 5.Right-handedness; 6.The patient's physical examination, medical history, vital signs, blood, urine and stool routine, liver and kidney function, electrolytes, electrocardiogram, electroencephalogram and other indicators are normal; 7.After fully understanding the safety of transcranial magnetic stimulation (TMS), they are willing to actively cooperate with the treatment and sign informed consent by themselves and their families.
Exclusion criteria
Exclusion criteria: 1.Age 60 years; 2.Those with a history of severe physical illness and depression due to other psychoactive and non-dependent substances; 3.Patients with metallic or electronic instruments placed in the body, such as intracranial metallic foreign bodies, cochlear implants, pacemakers and stents, and other metallic foreign bodies; 4.Patients at risk for seizures, with previous cranial disease, head trauma, alcoholism, EEG abnormalities, MRI evidence of structural abnormalities in the brain, or a family history of epilepsy; 5.Those with psychotic symptoms requiring a combination of should antipsychotic medications; 6.Received ECT or other physical therapy within 2 months prior to enrollment; 7.Refusal to sign the informed consent form;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical Scale Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Electromyographic changes;EEG changes;Near infrared functional imaging;nuclear magnetic; | — |
Countries
China
Contacts
Public ContactDongsheng Zhou
Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed