acute ischemic stroke
Conditions
Interventions
Experimental group:rhTNK-tPA
Sponsors
China-Japan Union Hospital of Jilin Universtiy
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Age = 18 years old, gender not limited; (2) MRS score 0-1 before onset; (3) AIS patients (onset<4.5 hours) who meet the clinical criterion for thrombolysis in accordance with the Chinese guidelines for the diagnosis and treatment of ischemic stroke and receive TNK thrombolysis therapy; (4) The patient or guardian voluntarily signs the informed consent form.
Exclusion criteria
Exclusion criteria: (1) The patient refused to participate in this study or refused to cooperate with the 90 day follow-up; (2) According to the researcher's judgment, it is not suitable to participate in this study or participating in this study may lead to the subjects face greater risks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The proportion of mRS score 0-1 on Day 90 ± 7 follow-up visit;Incidence of symptomatic intracranial hemorrhage within 48 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| the Proportion of mRS score 0-2 on Day 90 ± 7 follow-up visit;mRS level distribution on Day 90 ± 7;NIHSS score of 0-1 or The proportion of patiients whose NIHSS score improved by ? NIHSS = 4 points compared to baseline on 24 ± 12h, 7 ± 1d, or before discharge (whichever occurs first);The incidence of significant bleeding events in other parts within 90 days;90 day overall mortality rate;Incidence of adverse events/serious adverse events within 90 days; | — |
Countries
China
Contacts
Public ContactLu-mei Chi
China-Japan Union Hospital of Jilin Universtiy
Outcome results
None listed