Breast cancer
Conditions
Interventions
No opioid anesthesia regimen+deep anterior serratus plane block group:Anesthesia induction,intraoperative maintenance and postoperative recovery were performed without opioids.Pain was resolved by dee
Conventional anesthesia control Group:Sufentanil was used for anesthesia induction and intraoperative maintenance without deep anterior serratus plane block.
Sponsors
Lujiang County People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients>18 years old,<75 years old; 2. Patients who planned to undergo elective radical mastectomy in our hospital.
Exclusion criteria
Exclusion criteria: 1.the skin at the piercing site has infection,ulcers,or peripheral nerve lesions; 2.patients with cerebrovascular diseases,psychiatric diseases,etc.who can not complete nerve block and postoperative pain score; 3.chronic pain,long-term use of opioids,hormones or non-steroidal drugs; 4.local anesthetic allergy; 5.pregnant and lactating women; 6.moderate or above abnormal cardiopulmonary function:such as severe arrhythmia,heart block,heart failure, hypertrophic cardiomyopathy,dilated cardiomyopathy,pulmonary heart disease and serious valve disease,and respiratory failure; 7.patients with serious liver and kidney dysfunction(alanine aminotransferase>40u or aspartate aminotransferase>35u;urea nitrogen>8.2umoVL creatinine>133umol/l); 8.coagulation dysfunction(PT>17 seconds or APTT>47 seconds); 9.patients with glaucoma ,prostatic hypertrophy and other atropine prohibited; 10.are participating in other clinical trials,or have used other clinical trial drugs in the first 3 months of enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15 score before surgery and 1/3/30 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Analgesics used within 48 hours after surgery;Pain scores (NRS) after recovery, 1 day, 3 days, and 30 days after surgery;Preoperative neuropathic pain was assessed by IDpain and DN4 scales;Pain intensity and therapeutic effect were evaluated by NRS and BPI before surgery and 1/3/30 days after surgery; | — |
Countries
China
Contacts
Public ContactXing Chao
Lujiang County People's Hospital
Outcome results
None listed