Coronary atherosclerotic heart disease
Conditions
Interventions
S Group:Esketamine is pumped intraoperatively
Control Group:Saline is pumped intraoperatively
Sponsors
The Affiliated Hospital of Qingdao University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) ASAII.~IV 2) Be older than 18 years old 3) Elective off-pump coronary artery bypass transplantation 4) Patients and their families understand the content of the experimental protocol and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1) History of previous cardiac surgery; 2) History of previous mental illness and depression; 3) History of contraindications to anesthetics; 4) Combined with anemia, blood disorders or abnormal coagulation function; 5) Combined with severe liver and kidney impairment; 6) Co-existing infectious diseases; 7) Recent use of glucocorticoids or other drugs that affect the inflammatory response; 8) Those who are unable to cooperate with the investigators due to audio-visual or psychological diseases; 9) Alcohol or illicit drug abuse disorder.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative cognitive function;Interleukin-6;Death after operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| C-reactive protein;Ddosage of norepinephrine;Time to remove the endotracheal tube;Dosage of epinephrine;Dosage of dopamine;Dosage of posterior pituitary;Operative time;Anesthesia time;Time to regain consciousness;Postoperative nausea and vomiting;Postoperative respiratory depression;Delayed awakening;Unplanned secondary surgery; | — |
Countries
China
Contacts
Public ContactAijie Liu
The Affiliated Hospital of Qingdao University
Outcome results
None listed