Pain after posterior approach lumbar surgery
Conditions
Interventions
Bupivacaine liposome group:Bupivacaine liposomes 10mL(133mg)+ saline 20mL, 15mL on each side
Bupivacaine group:Bupivacaine hydrochloride 5mL(75mg)+ normal saline 25ml, 15mL on each side
Sponsors
the Second Hospital of Lanzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Before the test, understand the nature, significance, possible benefits, possible inconvenience and potential risks of the test in detail. Able to understand the procedures and methods of this study, and willing to strictly follow the clinical trial protocol to complete this study; 2. Posterior approach lumbar surgery should be performed at an appropriate time. 3. Age 18-65 years old; 4. American Society of Anesthesiologists (ASA) Grade I ~ III; 5. Consent of patients and their families was obtained before surgery, and informed consent was signed.
Exclusion criteria
Exclusion criteria: 1. Received bupivacaine liposomes or bupivacaine hydrochloride within the last 30 days. 2. Patients with a history of immunodeficiency diseases (such as congenital immunodeficiency disease, AIDS or malignant tumors) or who used immunosuppressants within 30 days before surgery. 3. Patients with a history of psychiatric diseases (such as schizophrenia, depression, etc.) or difficulties in communication. 4. Patients with a history of chronic pain or visceral pain. 5. Patients with abnormal liver and kidney function. 6. Patients with clinically significant abnormal heart rate or heartbeat rhythm during the screening period. 7. The investigator believes that there are any other reasons why the patient is not eligible to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood concentration of bupivacaine;Patient visual analogue score (VAS);Time to first use of a pressure relief pump (accurate to hours) and additional remedial analgesia usage;Cumulative use of opioids; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative consumption of propofol and remifentanil;QoR-15 score;Complications;overlengthy case in hospital stays; | — |
Countries
China
Contacts
Public ContactWang Yingbin
the Second Hospital of Lanzhou University
Outcome results
None listed