Hypertension obstructive sleep apnea cardiovascular disease
Conditions
Interventions
experimental group:Antihypertensive drugs combined with CPAP
Sponsors
Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Diagnosed as hypertension and OSA 2.Able to provide written informed consent 3. Age >= 18 years old;
Exclusion criteria
Exclusion criteria: 1. Patients with secondary hypertension due to other causes ( protoaldehyde, renal artery stenosis, etc.) 2. Patients who have been previously diagnosed with OSA and have been treated 3. Frequent use of other medications that affect blood pressure 4. It is difficult to take antihypertensive drugs regularly or may change the antihypertensive regimen within half a year 5. Occupations that require early or routine CPAP (drivers, machine operators, etc.) 6. Have other comorbidities (such as heart failure, malignant tumors, etc.) 7. Women who are pregnant and planning to become pregnant 8. Patients with severe renal insufficiency (creatinine clearance < 30 ml/min) or on dialysis 9. Those who were lost to follow-up after 3 months or had an average CPAP treatment duration of <4 hours or had difficulty taking antihypertensive drugs regularly 10. Psychosocial causes, alcohol or drug abuse that affect study participation and follow-up
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24h-sBP;24h-dBP; | — |
Countries
China
Contacts
Public ContactLiu Yuqi
Chinese PLA General Hospital
Outcome results
None listed