Cervical cancer
Conditions
Interventions
IMU group:IMU
Control group:None
Sponsors
Shanghai First Maternity and Infant Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Cervical cancer patients receiving radical chemoradiotherapy. 2.Pathological types include cervical squamous cell carcinoma, adenocarcinoma, and adenosquamous carcinoma. 3.FIGO 2008 staging: IIA-IVA (IIA, IIB, IIIA, IIIB, IIIC, IVA). 4.Measurable cervical lesions present before brachytherapy. 5.Subjects aged 18-75 years, with a Karnofsky Performance Status (KPS) score of =70. 6.Subjects with an expected survival of more than 6 months. 7.Good cardiac, pulmonary, liver, and kidney function, with no contraindications for radiotherapy. 8.Voluntarily enrolled participants with good compliance, able to cooperate with trial observations, and have signed a written informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients who cannot or are unwilling to undergo brachytherapy. 2.Patients with concurrent acute or chronic infectious diseases, gastrointestinal diseases, severe heart failure, severe liver or kidney dysfunction, or other diseases or complications. 3.Pregnant and lactating women. 4.Individuals with allergic constitutions. 5.Newly developed cardiovascular and cerebrovascular diseases within the last three months. 6.Individuals with coagulation disorders or abnormal immune systems. 7.Individuals with a history of positive serological testing for human immunodeficiency virus (HIV) detected through laboratory screening. 8.The investigator believes that there is any clinically significant history of disease or disorder that may put the patient at risk, affect the results, or impair the patient's ability to participate in the study (based on the interview).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of adverse events;clinical efficacy evaluation; | — |
Secondary
| Measure | Time frame |
|---|---|
| HRCTV D90 dose, rectum and bladder D2cc dose, number of interstitial needles, number of CT scans; | — |
Countries
China
Contacts
Public ContactLiang Yang
Shanghai First Maternity and Infant Hospital
Outcome results
None listed