Depression
Conditions
Interventions
iTBS combined with cTBS group:iTBS combined with cTBS cross sequential intervention
Sponsors
Affiliated Kangning Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Being 18 to 60 years of age; 2.According to the Diagnostic and Statistical Manual of Mental Disorders (DSM-V), two psychiatrists independently diagnose the patients as depression; 3.a total HAMD-24 score of >20; 4.Right-handedness; 5.The patient's physical examination, medical history, vital signs, blood, urine and stool routine, liver and kidney function, electrolytes, electrocardiogram, electroencephalogram and other indicators are normal; 6.After fully understanding the safety of transcranial magnetic stimulation (TMS), they are willing to actively cooperate with the treatment and sign informed consent by themselves and their families.
Exclusion criteria
Exclusion criteria: 1.Those with a history of severe physical illness and depression due to other psychoactive and non-dependent substances; 2.Patients with metallic or electronic instruments placed in the body, such as intracranial metallic foreign bodies, cochlear implants, pacemakers and stents, and other metallic foreign bodies; 3.Patients at risk for seizures, with previous cranial disease, head trauma, alcoholism, EEG abnormalities, MRI evidence of structural abnormalities in the brain, or a family history of epilepsy; 4.Those with psychotic symptoms requiring a combination of should antipsychotic medications; 5.Received ECT or other physical treatments within 2 months prior to enrollment. 6.Pregnant, breastfeeding, or planning to conceive during the trial period; 7.Refusal to sign the informed consent form;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical Scale Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Electromyographic changes;EEG changes;Near infrared functional imaging;nuclear magnetic;Behavioral tasks; | — |
Countries
China
Contacts
Public ContactLi xingxing
Affiliated Kangning Hospital of Ningbo University
Outcome results
None listed