septic shock
Conditions
Interventions
Experimental group (5% albumin group):Treatment with 5% albumin solution was administered according to the guidelines for fluid resuscitation in septic shock patients within the first 3 hours after fl
Control group (sodium acetate Ringer group):Treatment with sodium acetate Ringer’s solution was administered according to the guidelines for fluid resuscitation in septic shock patients within the fir
Sponsors
The First Affiliated Hospital of Naval Medical University (Shanghai Changhai Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Septic shock was diagnosed in patients who were considered by physicians for volumetric resuscitation. 1. The patients met the diagnostic criteria for "septic shock" (see "* Instructions" below). 2. The age range of the patients was 18-85 years old. 3. There were no gender restrictions for inclusion in the study. 4. Patients voluntarily consented or had agent consent to participate in the study and signed a written informed consent. * Description: The diagnostic criteria for septic shock are consistent with diagnosing sepsis combined with the following conditions: 1. After receiving adequate fluid resuscitation, vasoactive drugs were still required to maintain mean arterial pressure =65 mmHg. 2. Serum lactic acid levels remained >2 mmol/L after adequate fluid resuscitation. Suspected infection and qSOFA score =2 were used as diagnostic criteria for sepsis. qSOFA scoring criteria: 1. Respiratory rate =22 times/min 2. Glasgow coma score <15 3.Systolic blood pressure <100mmHg
Exclusion criteria
Exclusion criteria: 1.Shock caused by other etiologies; 2.History of previous adverse reactions to human blood albumin; 3.Traumatic brain injury; 4.Plasma exchange therapy; 5.Presence of severe organic cardiopulmonary disease (NYHA grade III-IV); 6.Pregnancy status; 7.Participation in another concurrent intervention study; 8.Refusal to participate in the experiment due to religious beliefs; 9.Patients deemed ineligible for the study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day all-cause mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure;Types of vasoactive drugs;Vasoactive drug dosage;Daily fluid intake;Daily fluid output;Marshall score;SOFA score;APACHE - II score;Mechanical ventilation duration;ICU length of stay;ICU hospitalization costs;CRRT treatment time;total blood transfusion volume; | — |
Countries
China
Contacts
Public ContactXiaojian Wan
The First Affiliated Hospital of Naval Medical University (Shanghai Changhai Hospital)
Outcome results
None listed