Cognitive dysfunction
Conditions
Interventions
Huntington's disease group:None
Elderly health group:None
Depression group:None
Schizophrenia group:None
Perioperative neurocognitive impairment group:None
Stroke group:None
Sponsors
Shanghai Fourth People's Hospital (Shanghai Fourth People's Hospital Affiliated to Tongji University)
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Young and elderly healthy participants Inclusion criteria: Gender and ethnicity are not limited; Youth group (18-40 years old), elderly group (60-90 years old); Clear consciousness; The patient agrees to be enrolled and signs the clinical informed consent form to participate in this study; 2. Patients with cognitive function related neurological disorders Inclusion criteria:Diagnosed with one or more of stroke, epilepsy, Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), sleep disorders, depression, schizophrenia, perioperative neurocognitive disorders; It has been assessed that there is a certain degree of cognitive impairment; Agree to participate in this study and sign the informed consent form
Exclusion criteria
Exclusion criteria: 1. Young and elderly healthy participants Exclusion criteria: long-term use of psychotropic drugs; Suffering from mental or psychological disorders or having a family history of genetic disorders; Accompanied by language and visual impairments; Malignant tumors, immune related diseases, diabetes and other metabolic diseases; Patients who have participated in other relevant clinical studies within the past three months. 2. Patients with cognitive function related neurological disorders Exclusion criteria: Refusal to participate in this study; Unable to complete the assessment due to severe dementia, language barriers, and other conditions; Severe heart, liver, and kidney dysfunction: patients with preoperative ASA grade = IV; Blood creatinine>442 µ mol/L, with or without blood potassium>6.5 mmol/L, or clinical doctors consider renal replacement therapy necessary; Child Pugh classification C; The attending physician or researcher believes that there are other circumstances that are not suitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All proteins in the blood;Partial plasma protein content;All metabolites in serum;Mini-Mental State Examination score ;Montreal Cognitive Assessment score ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient Health Questionnaire 9;MDS Unified Parkinson's Disease Rating Scale;Pittsburgh Sleep Quality Index;All microorganisms in feces;All proteins in urine;All metabolite in urine;All metabolite in feces;All protein levels in feces; | — |
Countries
China
Contacts
Public ContactXinwei Huang
Shanghai Fourth People's Hospital (Shanghai Fourth People's Hospital Affiliated to Tongji University)
Outcome results
None listed