Repeated dryness and desquamation of lips, with/without pain, pruritus and other symptoms, the duration of symptoms >2 months
Conditions
Interventions
Treated group:Topical applied lipstick on lips
Control group:Maintain the original nursing plan
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1.Sign the informed consent, promise to abide by the research procedures, and cooperate with the implementation of the whole process of research; 2.Adult female volunteers aged 20-45 years, generally in good condition; 3.Repeated dryness and desquamation of lips, with/without pain, pruritus and other symptoms, the duration of symptoms >2 months; According to the Liborija Lugovi-Mihi classification of cheilitis, the clinical diagnosis of reversible cheilitis includes (simple cheilitis, keratitis, contact cheilitis or eczematous cheilitis, exfoliative cheilitis, drug-associated cheilitis). 4.Lips were washed with normal saline, and after sitting for 30 minutes, the study physician evaluated the degree of dryness of lips as mild to moderate (dryness score <=5). 5.During the test, it can adhere to and cooperate with the specified products; 6.Agree not to use lip products of the same category as the test sample during the test; 7.During the test period, agree not to use any cosmetic products that may affect the results (except for the commitment to maintain the daily lip care routine and lip skin care products used during the 2 weeks prior to the test period and during the test period), drugs and health care products; 8.Subjects should not use moisturizing lip products for 24 hours prior to each visit; 9.In fertile women, contraception should be used for at least one month prior to screening, and they should commit to use contraception throughout the study period and continue until the specified time after the study; 10.No longer participate in clinical trials at any other research center during the trial period;
Exclusion criteria
Exclusion criteria: 1.Suffering from serious systemic or mental illness; 2.Patients with other oral mucosal diseases; 3.According to the classification of cheilitis by Liborija Lugovi-Mihi, persistent cheilitis (actinic cheilitis, granulomatous cheilitis, glandular cheilitis, plasma cell cheilitis, etc.) and specific and systemic disease associated cheilitis (erythematosus erythematosus, lichen planus, Crohn's disease, etc.) were excluded. 4.Participants were currently using systemic or topical corticosteroids, immunosuppressants, calcineurin inhibitors, antihistamines, retinoids, biologics, etc., or within one month prior to the start of the study; 5.Smokers, alcohol drinkers, and those who cannot avoid external factors that cause lip inflammation; 6.History of skin or other diseases that may affect the results of the test and other conditions that preclude the use of the test sample; 7.Currently enrolled in another clinical trial or within 3 months prior to the start of this study; 8.Participants who had done lip beauty programs at present or within 3 months before the study began; 9.Pregnant, lactating, or planning to become pregnant; 10.In addition to the above, if it is deemed inappropriate to conduct the test in the judgment of the study leader;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement rate of objective symptoms of cheilitis;Lip dryness improvement rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement rate of affected lip area ;Lip dryness improvement rate; | — |
Countries
China
Contacts
Public ContactXia Li
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed