sepsis
Conditions
Interventions
Non-infected controls:None
Sponsors
Zhongshan Hospital Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Septic patients (1) 18-85 years old, male or female; (2) Clearly with bacterial infection (types of pathogens and primary disease are not limited); (3) SOFA= 2; (4)From whom written informed consent is obtainable either from the patient or from a legal representative. 2. Non-infected controls (1) 18-85 years old, male or female; (2) No evidence of infection; (3) From whom written informed consent is obtainable either from the patient or from a legal representative.
Exclusion criteria
Exclusion criteria: (1) >85 years old or <18 years old; (2) Participation in Organ transplant within a month; (3) Patients with active cancer, patients with a history of cancer were not excluded; Active cancer patients include patients who are planned for undergoing cancer surgery, are receiving anticancer drug(s) and/or radiotherapy, and have recurrent, metastatic, and/or inoperable cancer. Patients with cancer history include the tumor has been successfully treated and patients is not currently in the treatment phase, or the tumor has been resected and there is no evidence of recurrence, or patients are currently receiving adjuvant therapy (e.g., Lupron or tamoxifen) for prophylaxis. (4) Patients with human immunodeficiency virus/acquired immunodeficiency syndrome; (5) Patients with autoimmune diseases; (6) Participation in other drug trials in the 30 days prior to enrollment; (7) Parturient or breast-feeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The propotion of DPEP2+ macrophage in peripheral blood;Inflammatory markers in peripheral blood; | — |
Secondary
| Measure | Time frame |
|---|---|
| SOFA score;In-hospital mortality;28-day post-discharge mortality;Concentration of DPEP2 in peripheral blood; | — |
Countries
China
Contacts
Public ContactJing Zhong
Zhongshan Hospital Fudan University
Outcome results
None listed