coronary heart disease
Conditions
Interventions
Esketamine group:0.2mg/kg/h esketamine pumped via cvp after central venous placement
control group:50 ml syringe pumped into saline, pumped 0.2 mg/kg/h
Sponsors
Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Patients aged =18 years , with a BMI of 18.5 to 23.9 kg/m^2, and those aged 65 years or older with a BMI of 20 to 26.9 kg/m^2 who underwent nonstop cardiac coronary artery transplantation.
Exclusion criteria
Exclusion criteria: a. Patients with hepatic or renal failure. b. Ketamine Ketamine allergy. c. Psychiatric illness or history of psychiatric drug use. History of drug abuse. d. Patients with uncontrolled hypertension, increased intracranial pressure, high intraocular pressure, and patients with hyperthyroidism. e. Patients taking medications that affect immune function. f. History of cardiac major vascular surgery. g. Preoperative radiotherapy and chemotherapy. h. Patients who are unable to complete the scale assessment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative circulatory stability;NRS scores 1, 2, and 3 days after awake extubation;Anxiety, depression scores;postoperative adverse reaction;Extubation and hospitalization time;Postoperative review of CTA results;30-day postoperative mortality rate; | — |
Countries
China
Contacts
Public ContactYi Chang
Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital)
Outcome results
None listed